KFU. Card publication. Transcription factor TnrA inhibits the biosynthetic activity of glutamine synthetase in Bacillus subtilis.

KAZAN
FEDERAL UNIVERSITY

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TRANS&SHY;CRIPTION FACTOR TNRA INHIBITS THE BIOSYNTHETIC ACTIVITY OF GLUTAMINE SYNTHETASE IN BACILLUS SUBTILIS.

Form of presentation

Articles in international journals and collections

Year of publication

2013

Authors, employees of KFU

Ilinskaya Olga Nikolaevna, author

Kayumov Ayrat Rashitovich, author

Fedorova Kseniya Pavlovna, author

Other authors

Kathrin Woyda; Karl Forchhammer

Bibliographic description in the original language

Ksenia Fedorova, Airat Kayumov, Kathrin Woyda, Olga Ilinskaja, Karl Forchhammer. Transcription factor TnrA inhibits the biosynthetic activity of glutamine synthetase in Bacillus subtilis // Febs Letter. - 2013. - V. 587, I. 9. - P. 1293-1298.

Annotation

FEBS LETT

Keywords

Bacillus subtilis, nitrogen metabolism, glutamine synthetase, transcription factor TnrA

The name of the journal

FEBS LETT

URL

http://www.febsletters.org/article/S0014-5793(13)00226-3/abstract

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=64996&p_lang=2

Resource files

File name	Size (MB)	Format
febs.pdf	0,12	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Ilinskaya Olga Nikolaevna	ru_RU
dc.contributor.author	Kayumov Ayrat Rashitovich	ru_RU
dc.contributor.author	Fedorova Kseniya Pavlovna	ru_RU
dc.date.accessioned	2013-01-01T00:00:00Z	ru_RU
dc.date.available	2013-01-01T00:00:00Z	ru_RU
dc.date.issued	2013	ru_RU
dc.identifier.citation	Ksenia Fedorova, Airat Kayumov, Kathrin Woyda, Olga Ilinskaja, Karl Forchhammer. Transcription factor TnrA inhibits the biosynthetic activity of glutamine synthetase in Bacillus subtilis // Febs Letter. - 2013. - V. 587, I. 9. - P. 1293-1298.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=64996&p_lang=2	ru_RU
dc.description.abstract	FEBS LETT	ru_RU
dc.description.abstract	FEBS LETT	ru_RU
dc.description.abstract	The Bacillus subtilis glutamine synthetase (GS) plays a dual role in cell metabolism by functioning as catalyst and regulator. GS catalyses the ATP-dependent synthesis of glutamine from glutamate and ammonium. Under nitrogen-rich conditions, GS becomes feedback-inhibited by high intracellular glutamine levels and then binds transcription factors GlnR and TnrA, which control the genes of nitrogen assimilation. While GS-bound TnrA is no longer able to interact with DNA, GlnR?DNA binding is shown to be stimulated by GS complex formation. In this paper we show a new physiological feature of the interaction between glutamine synthetase and TnrA. The transcription factor TnrA inhibits the biosynthetic activity of glutamine synthetase in vivo and in vitro, while the GlnR protein does not affect the activity of the enzyme.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Bacillus subtilis	ru_RU
dc.subject	nitrogen metabolism	ru_RU
dc.subject	glutamine synthetase	ru_RU
dc.subject	transcription factor TnrA	ru_RU
dc.title	Transcription factor TnrA inhibits the biosynthetic activity of glutamine synthetase in Bacillus subtilis.	ru_RU
dc.type	Articles in international journals and collections	ru_RU