KFU. Card publication. Antifungal activity of oligochitosans (short chain chitosans) against some Candida species and clinical isolates of Candida albicans: Molecular weight-activity relationship

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ANTIFUNGAL ACTIVITY OF OLIGOCHITOSANS (SHORT CHAIN CHITOSANS) AGAINST SOME CANDIDA SPECIES AND CLINICAL ISOLATES OF CANDIDA ALBICANS: MOLECULAR WEIGHT-ACTIVITY RELATIONSHIP

Form of presentation

Articles in Russian journals and collections

Year of publication

2014

Authors, employees of KFU

Zelenikhin Pavel Valerevich, author

Other authors

S.N. Kulikov; S.A. Lisovskaya;E.A. Bezrodnykh; D.R. Shakirova; I.V. Blagodatskikh; V.E. Tikhonov

Bibliographic description in the original language

Kulikov, S.N. Antifungal activity of oligochitosans (short chain chitosans) against some Candida species and clinical isolates of Candida albicans: Molecular weight-activity relationship [Text] / S.N. Kulikov, S.A. Lisovskaya, P.V. Zelenikhin, E.A. Bezrodnykh, D.R. Shakirova, I.V. Blagodatskikh, V.E. Tikhonov // Eur J Med Chem.- 2013.- V.74C.- P.169-178.

Annotation

Eur J Med Chem

Keywords

Activity, Candida, Chitosan, Cytometry, Hyphae, Oligochitosan, TEM

The name of the journal

Eur J Med Chem

URL

http://www.sciencedirect.com/science/article/pii/S0223523413008052

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=79006&p_lang=2

Resource files

File name	Size (MB)	Format
1_s2.0_S0223523413008052_main.pdf	1,28	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Zelenikhin Pavel Valerevich	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Kulikov, S.N. Antifungal activity of oligochitosans (short chain chitosans) against some Candida species and clinical isolates of Candida albicans: Molecular weight-activity relationship [Text] / S.N. Kulikov, S.A. Lisovskaya, P.V. Zelenikhin, E.A. Bezrodnykh, D.R. Shakirova, I.V. Blagodatskikh, V.E. Tikhonov // Eur J Med Chem.- 2013.- V.74C.- P.169-178.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=79006&p_lang=2	ru_RU
dc.description.abstract	Eur J Med Chem	ru_RU
dc.description.abstract	Eur J Med Chem	ru_RU
dc.description.abstract	A series of oligochitosans (short chain chitosans) prepared by acidic hydrolysis of chitosan and characterized by their molecular weight, polydispersity and degree of deacetylation were used to determine their anticandidal activities. This study has demonstrated that oligochitosans show a high fungistatic activity (MIC 8-512 μg/ml) against Candida species and clinical isolates of Candida albicans, which are resistant to a series of classic antibiotics. Flow cytometry analysis showed that oligochitosan possessed a high fungicidal activity as well. For the first time it was shown that even sub-MIC oligochitosan concentration suppressed the formation of C. albicans hyphal structures, cause severe cell wall alterations, and altered internal cell structure. These results indicate that oligochitosan should be considered as a possible alternative/additive to known anti-yeast agents in pharmaceutical compositions.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Activity	ru_RU
dc.subject	Candida	ru_RU
dc.subject	Chitosan	ru_RU
dc.subject	Cytometry	ru_RU
dc.subject	Hyphae	ru_RU
dc.subject	Oligochitosan	ru_RU
dc.subject	TEM	ru_RU
dc.title	Antifungal activity of oligochitosans (short chain chitosans) against some Candida species and clinical isolates of Candida albicans: Molecular weight-activity relationship	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU