Form of presentation | Articles in Russian journals and collections |
Year of publication | 2014 |
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Bakhtiyarova Yuliya Valerevna, author
Galkin Vladimir Ivanovich, author
Galkina Irina Vasilevna, author
Islamov Daut Rinatovich, author
Kataeva Olga Nikolaevna, author
Cherkasov Rafael Askhatovich, author
Chubukaeva Dinara Rashitovna, author
|
Bibliographic description in the original language |
I.V. Galkinaa, D. R. Chubukaevaa, Yu.V.Bakhtiyarovaa, V.I. Galkina, R.A. Cherkasova, D. R. Islamova, and O.N. Kataeva, Modification of the Anticestodal Drug 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide with a View to Improve Its Biological Effect,Russian Journal of Organic Chemistry, 2014, Vol.50, No 6, pp.812-822.DOI: 10.1134/S1070428014060074 |
Annotation |
?Reactions of 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide, the active substance of the drug Niclosamide (Phenasal), with higher amines (dodecan-1-amine, hexadecan-1-amine) and 1-(2-aminoethyl)-piperazine lead to the formation of the corresponding water-soluble ammonium salts with retention of pharmacophoric groups responsible for the antihelminthic effect, whereas no nucleophilic aromatic substitution of chlorine is observed. The product structure was determined by X-ray analysis. |
Keywords |
anticestodal drug, modification, biological effect, 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide |
The name of the journal |
J ORG CHEM
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Please use this ID to quote from or refer to the card |
https://repository.kpfu.ru/eng/?p_id=83922&p_lang=2 |
Resource files | |
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Full metadata record ![](https://shelly.kpfu.ru/pdf/picture/arrow_black_right.gif) |
Field DC |
Value |
Language |
dc.contributor.author |
Bakhtiyarova Yuliya Valerevna |
ru_RU |
dc.contributor.author |
Galkin Vladimir Ivanovich |
ru_RU |
dc.contributor.author |
Galkina Irina Vasilevna |
ru_RU |
dc.contributor.author |
Islamov Daut Rinatovich |
ru_RU |
dc.contributor.author |
Kataeva Olga Nikolaevna |
ru_RU |
dc.contributor.author |
Cherkasov Rafael Askhatovich |
ru_RU |
dc.contributor.author |
Chubukaeva Dinara Rashitovna |
ru_RU |
dc.date.accessioned |
2014-01-01T00:00:00Z |
ru_RU |
dc.date.available |
2014-01-01T00:00:00Z |
ru_RU |
dc.date.issued |
2014 |
ru_RU |
dc.identifier.citation |
I.V. Galkinaa, D. R. Chubukaevaa, Yu.V.Bakhtiyarovaa, V.I. Galkina, R.A. Cherkasova, D. R. Islamova, and O.N. Kataeva, Modification of the Anticestodal Drug 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide with a View to Improve Its Biological Effect,Russian Journal of Organic Chemistry, 2014, Vol.50, No 6, pp.812-822.DOI: 10.1134/S1070428014060074 |
ru_RU |
dc.identifier.uri |
https://repository.kpfu.ru/eng/?p_id=83922&p_lang=2 |
ru_RU |
dc.description.abstract |
J ORG CHEM |
ru_RU |
dc.description.abstract |
?Reactions of 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide, the active substance of the drug Niclosamide (Phenasal), with higher amines (dodecan-1-amine, hexadecan-1-amine) and 1-(2-aminoethyl)-piperazine lead to the formation of the corresponding water-soluble ammonium salts with retention of pharmacophoric groups responsible for the antihelminthic effect, whereas no nucleophilic aromatic substitution of chlorine is observed. The product structure was determined by X-ray analysis. |
ru_RU |
dc.language.iso |
ru |
ru_RU |
dc.subject |
anticestodal drug |
ru_RU |
dc.subject |
modification |
ru_RU |
dc.subject |
biological effect |
ru_RU |
dc.subject |
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide |
ru_RU |
dc.title |
Modification of the Anticestodal Drug 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide with a View to Improve Its Biological Effect. |
ru_RU |
dc.type |
Articles in Russian journals and collections |
ru_RU |
|