KFU. Card publication. Low molecular weight polyethylene glycols as matrix to obtain solid dispersions of sulfanilamide

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FEDERAL UNIVERSITY

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LOW MOLECULAR WEIGHT POLYETHYLENE GLYCOLS AS MATRIX TO OBTAIN SOLID DISPERSIONS OF SULFANILAMIDE

Form of presentation

Articles in international journals and collections

Year of publication

2014

Authors, employees of KFU

Gerasimov Aleksandr Vladimirovich, author

Gorbachuk Valeriy Vilenovich, author

Ziganshin Marat Akhmedovich, author

Authors, students KFU

Usmanova Liana Stanislavovna, author

Bibliographic description in the original language

Gerasimov, A.V. Low molecular weight polyethylene glycols as matrix to obtain solid dispersions of sulfanilamide / A.V. Gerasimov, M.A. Ziganshin, V.V. Gorbatchuk, L.S. Usmanova // International Journal of Pharmacy and Pharmaceutical Sciences. – 2014. – V.6, N.6. – P.372-377.

Annotation

Objective: The objective of the present study is a determination of optimal ratios of polyethylene glycol:sulfanilamide at which formation of solid dispersion is observed. Also study the effect of the polymer on the limiting solubility of sulfanilamide in water. Methods: Using low-temperature differential scanning calorimetry (DSC), it was made possible to obtain solid dispersions of sulfanilamide with polyethylene glycols having average molecular weight 1000 and 1400. UV-spectroscopy was used to determine the effect of polymer on limiting solubility of sulfanilamide. Results: An optimal polymer:sulfanilamide ratios are 7:1 and 4:1 for PEG-1000 and PEG-1400, respectively. Polymer in a drug composition allows for the increase the sulfanilamide content in water up to 3.0 times as compared with the solution of individual drug. Conclusion: These promising materials can be used for manufacture of drugs in various forms: capsular drugs, ointment and suppositories.

Keywords

Solid dispersion, Sulfanilamide, Polyethylene glycol, Differential scanning calorimetry

The name of the journal

International Journal of Pharmacy and Pharmaceutical Sciences

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=84284&p_lang=2

Resource files

File name	Size (MB)	Format
IJPPS_2014.pdf	0,38	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Gerasimov Aleksandr Vladimirovich	ru_RU
dc.contributor.author	Gorbachuk Valeriy Vilenovich	ru_RU
dc.contributor.author	Ziganshin Marat Akhmedovich	ru_RU
dc.contributor.author	Usmanova Liana Stanislavovna	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Gerasimov, A.V. Low molecular weight polyethylene glycols as matrix to obtain solid dispersions of sulfanilamide / A.V. Gerasimov, M.A. Ziganshin, V.V. Gorbatchuk, L.S. Usmanova // International Journal of Pharmacy and Pharmaceutical Sciences. – 2014. – V.6, N.6. – P.372-377.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=84284&p_lang=2	ru_RU
dc.description.abstract	International Journal of Pharmacy and Pharmaceutical Sciences	ru_RU
dc.description.abstract	Objective: The objective of the present study is a determination of optimal ratios of polyethylene glycol:sulfanilamide at which formation of solid dispersion is observed. Also study the effect of the polymer on the limiting solubility of sulfanilamide in water. Methods: Using low-temperature differential scanning calorimetry (DSC), it was made possible to obtain solid dispersions of sulfanilamide with polyethylene glycols having average molecular weight 1000 and 1400. UV-spectroscopy was used to determine the effect of polymer on limiting solubility of sulfanilamide. Results: An optimal polymer:sulfanilamide ratios are 7:1 and 4:1 for PEG-1000 and PEG-1400, respectively. Polymer in a drug composition allows for the increase the sulfanilamide content in water up to 3.0 times as compared with the solution of individual drug. Conclusion: These promising materials can be used for manufacture of drugs in various forms: capsular drugs, ointment and suppositories.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Solid dispersion	ru_RU
dc.subject	Sulfanilamide	ru_RU
dc.subject	Polyethylene glycol	ru_RU
dc.subject	Differential scanning calorimetry	ru_RU
dc.title	Low molecular weight polyethylene glycols as matrix to obtain solid dispersions of sulfanilamide	ru_RU
dc.type	Articles in international journals and collections	ru_RU