KFU. Card publication. Increasing the solubility of dipyridamole using polyethylene glycols

KAZAN
FEDERAL UNIVERSITY

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INCREASING THE SOLUBILITY OF DIPYRIDAMOLE USING POLYETHYLENE GLYCOLS

Form of presentation

Articles in international journals and collections

Year of publication

2014

Authors, employees of KFU

Gerasimov Aleksandr Vladimirovich, author

Gorbachuk Valeriy Vilenovich, author

Ziganshin Marat Akhmedovich, author

Authors, students KFU

Usmanova Liana Stanislavovna, author

Bibliographic description in the original language

Gerasimov, A.V. Increasing the solubility of dipyridamole using polyethylene glycols / A.V. Gerasimov, M.A. Ziganshin, V.V. Gorbatchuk, L.S. Usmanova // International Journal of Pharmacy and Pharmaceutical Sciences. – 2014. – V.6, N.9. – P.244-247.

Annotation

Objective: The objective of the present study is a determination of limiting solubility of dipyridamole in water and optimal ratios of polyethylene glycol:dipyridamole at which formation of solid dispersion is observed. Methods: UV-spectroscopy was used to determine the effect of polymer on limiting solubility of dipyridamole. Using low-temperature differential scanning calorimetry (DSC), it was made possible to obtain solid dispersions of dipyridamole with polyethylene glycols having average molecular weight 1000 and 1400. Results: The optimal ratio of polymer:drug is 1:1, and is 3:1 for PEG-1000 and PEG-1400 respectively. Joint dissolution of dipyridamole with PEG-1400 and PEG-1000 increases the drug content in water by up to 8.1 times and up to 175 times, compared with the solution containing only dipyridamole. Conclusion: Using systems based on dipyridamole and polyethylene glycol with average molecular weight of 1000, may increase the bioavailability of the drug and consequently reduce the dosages. Wide range of ratios, in which the formation of solid dispersions is possible, enables to adjust the solubility of dipyridamole in neutral aqueous media.

Keywords

dipyridamole; polyethylene glycol; solubility in water; solid dispersion; differential scanning calorimetry; UV spectroscopy

The name of the journal

International Journal of Pharmacy and Pharmaceutical Sciences

URL

http://innovareacademics.in/journals/index.php/ijpps/article/view/2107

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=86445&p_lang=2

Resource files

File name	Size (MB)	Format
IJPPS_2014_2_.pdf	0,36	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Gerasimov Aleksandr Vladimirovich	ru_RU
dc.contributor.author	Gorbachuk Valeriy Vilenovich	ru_RU
dc.contributor.author	Ziganshin Marat Akhmedovich	ru_RU
dc.contributor.author	Usmanova Liana Stanislavovna	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Gerasimov, A.V. Increasing the solubility of dipyridamole using polyethylene glycols / A.V. Gerasimov, M.A. Ziganshin, V.V. Gorbatchuk, L.S. Usmanova // International Journal of Pharmacy and Pharmaceutical Sciences. – 2014. – V.6, N.9. – P.244-247.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=86445&p_lang=2	ru_RU
dc.description.abstract	International Journal of Pharmacy and Pharmaceutical Sciences	ru_RU
dc.description.abstract	Objective: The objective of the present study is a determination of limiting solubility of dipyridamole in water and optimal ratios of polyethylene glycol:dipyridamole at which formation of solid dispersion is observed. Methods: UV-spectroscopy was used to determine the effect of polymer on limiting solubility of dipyridamole. Using low-temperature differential scanning calorimetry (DSC), it was made possible to obtain solid dispersions of dipyridamole with polyethylene glycols having average molecular weight 1000 and 1400. Results: The optimal ratio of polymer:drug is 1:1, and is 3:1 for PEG-1000 and PEG-1400 respectively. Joint dissolution of dipyridamole with PEG-1400 and PEG-1000 increases the drug content in water by up to 8.1 times and up to 175 times, compared with the solution containing only dipyridamole. Conclusion: Using systems based on dipyridamole and polyethylene glycol with average molecular weight of 1000, may increase the bioavailability of the drug and consequently reduce the dosages. Wide range of ratios, in which the formation of solid dispersions is possible, enables to adjust the solubility of dipyridamole in neutral aqueous media.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Increasing the solubility of dipyridamole using polyethylene glycols	ru_RU
dc.type	Articles in international journals and collections	ru_RU