KFU. Card publication. Macrocyclic derivatives of 6-methyluracil as ligands of the peripheral anionic site of acetylcholinesterase

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FEDERAL UNIVERSITY

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MACROCYCLIC DERIVATIVES OF 6-METHYLURACIL AS LIGANDS OF THE PERIPHERAL ANIONIC SITE OF ACETYLCHOLINESTERASE

Form of presentation

Articles in international journals and collections

Year of publication

2014

Authors, employees of KFU

Zobov Vladimir Vasilevich, author

Bibliographic description in the original language

Semenov, V.E. Macrocyclic derivatives of 6-methyluracil as ligands of the peripheral anionic site of acetylcholinesterase / V.E. Semenov, R.Kh. Giniyatullin, S.V. Lushchekina, E.D. Kots, K.A. Petrov, A.D. Nikitashina, O.A. Minnekhanova, V.V. Zobov, E.E. Nikolsky, P. Masson, V.S. Reznik // MedChemComm. -2014, V. 5, Issue 11, -P. 1729-1735

Annotation

Novel pyrimidinophanes possessing two o-nitrobenzylethyldialkylammonium heads bridging with different spacers were prepared. Pyrimidinophanes 2a, 2b and 3 are reversible inhibitors of cholinesterases. They show a very good selectivity for human acetylcholinesterase (AChE), with an inhibitory power 100?200 times higher than for human butyrylcholinesterase (BChE). Docking simulations indicate specific binding of pyrimidinophanes 2a and 4 onto the peripheral anionic site of AChE. Other compounds bind to the active center of AChE as well as to the peripheral anionic site. These compounds are dual binding site inhibitors. Pyrimidinophane 2b and its acyclic counterpart 1 were tested in the animal model of myasthenia gravis and may be considered as valuable candidates for the treatment of pathological muscle weakness syndromes

Keywords

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The name of the journal

Med. Chem. Commun.

URL

http://pubs.rsc.org/en/content/articlelanding/2014/md/c4md00225c#!divAbstract

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=91845&p_lang=2

Resource files

File name	Size (MB)	Format
MedChemComm_2014.pdf	0,75	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Zobov Vladimir Vasilevich	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Semenov, V.E. Macrocyclic derivatives of 6-methyluracil as ligands of the peripheral anionic site of acetylcholinesterase / V.E. Semenov, R.Kh. Giniyatullin, S.V. Lushchekina, E.D. Kots, K.A. Petrov, A.D. Nikitashina, O.A. Minnekhanova, V.V. Zobov, E.E. Nikolsky, P. Masson, V.S. Reznik // MedChemComm. -2014, V. 5, Issue 11, -P. 1729-1735	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=91845&p_lang=2	ru_RU
dc.description.abstract	Med. Chem. Commun.	ru_RU
dc.description.abstract	Novel pyrimidinophanes possessing two o-nitrobenzylethyldialkylammonium heads bridging with different spacers were prepared. Pyrimidinophanes 2a, 2b and 3 are reversible inhibitors of cholinesterases. They show a very good selectivity for human acetylcholinesterase (AChE), with an inhibitory power 100?200 times higher than for human butyrylcholinesterase (BChE). Docking simulations indicate specific binding of pyrimidinophanes 2a and 4 onto the peripheral anionic site of AChE. Other compounds bind to the active center of AChE as well as to the peripheral anionic site. These compounds are dual binding site inhibitors. Pyrimidinophane 2b and its acyclic counterpart 1 were tested in the animal model of myasthenia gravis and may be considered as valuable candidates for the treatment of pathological muscle weakness syndromes	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	��	ru_RU
dc.subject	��	ru_RU
dc.subject	��	ru_RU
dc.title	Macrocyclic derivatives of 6-methyluracil as ligands of the peripheral anionic site of acetylcholinesterase	ru_RU
dc.type	Articles in international journals and collections	ru_RU