KFU. Card publication. The Study of the Biological Activity of Amino-Substituted Benzofuroxans

KAZAN
FEDERAL UNIVERSITY

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THE STUDY OF THE BIOLOGICAL ACTIVITY OF AMINO-SUBSTITUTED BENZOFUROXANS

Form of presentation

Articles in international journals and collections

Year of publication

2014

Authors, employees of KFU

Zobov Vladimir Vasilevich, author

Bibliographic description in the original language

Chugunova, E.A. The Study of the Biological Activity of Amino-Substituted Benzofuroxans / E.A. Chugunova, A.D. Voloshina, R.E. Mukhamatdinova, I.V. Serkov, A.N. Proshin, E.M. Gibadullina, A.R. Burilov, N.V. Kulik, V.V. Zobov, D.B. Krivolapov, A.B. Dobrynin, R. Goumont // Letters in Drug Design & Discovery. -2014, -V. 11, № 4. –P. 502-512

Annotation

Letters in Drug Design & Discovery

Keywords

бензофуроксаны, токсичность, антимикробная активность

The name of the journal

Letters in Drug Design & Discovery

URL

http://eurekaselect.com/118238

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=91848&p_lang=2

Resource files

File name	Size (MB)	Format
Letters.in.Drug.Design_2014.pdf	0,37	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Zobov Vladimir Vasilevich	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Chugunova, E.A. The Study of the Biological Activity of Amino-Substituted Benzofuroxans / E.A. Chugunova, A.D. Voloshina, R.E. Mukhamatdinova, I.V. Serkov, A.N. Proshin, E.M. Gibadullina, A.R. Burilov, N.V. Kulik, V.V. Zobov, D.B. Krivolapov, A.B. Dobrynin, R. Goumont // Letters in Drug Design & Discovery. -2014, -V. 11, № 4. –P. 502-512	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=91848&p_lang=2	ru_RU
dc.description.abstract	Letters in Drug Design & Discovery	ru_RU
dc.description.abstract	Letters in Drug Design & Discovery	ru_RU
dc.description.abstract	As a part of our ongoing studies in developing new derivatives as dual antibacterial/antifungal agents, we describe the synthesis of novel amino substituted benzofuroxan derivatives. These compounds were tested for their antifungal activity against various strains. It is shown that their antimicrobial and antifungal activities depend on the structure of the amino moiety, on the position and on the nature of the substituents of the benzofuroxan ring. They displayed good bacteriostatic and fungistatic activities comparable to those of reference drugs. The more active benzofuroxan derivatives have been studied intraperitoneally in mice to get a first estimation of their toxicity. Preliminary results have also shown that some derivatives are able to inhibit enzymes such as GDH (glucose dehydrogenase)	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	бензофуроксаны	ru_RU
dc.subject	токсичность	ru_RU
dc.subject	антимикробная активность	ru_RU
dc.title	The Study of the Biological Activity of Amino-Substituted Benzofuroxans	ru_RU
dc.type	Articles in international journals and collections	ru_RU