| Form of presentation | Articles in international journals and collections |
| Year of publication | 2014 |
| Язык | русский |
|
Ilinskaya Olga Nikolaevna, author
Nesmelov Aleksandr Aleksandrovich, author
|
| Bibliographic description in the original language |
Azat R. Garipov, Alexander A. Nesmelov, Hector A. Cabrera-Fuentes, Olga N. Ilinskaya, Bacillus intermedius ribonuclease (BINASE) induces apoptosis in human ovarian cancer cells, Toxicon, Volume 92, 15 December 2014, Pages 54-59, ISSN 0041-0101, http://dx.doi.org/10.1016/j.toxicon.2014.09.014. |
| Annotation |
The cytotoxic effects ofBacillus intermediusRNase (binase) towards ovarian cancer cells
(SKOV3 and OVCAR5) were studied in comparison to normal ovarian epithelial cells (HOSE1
and HOSE2). Binase decreased viability and induced the selective apoptosis of ovarian cancer
cells. The apoptosis rate was 50% in SKOV3 and 48% in OVCAR5 cells after 24 h of binase treatment (50 mg/ml). Binase-induced apoptosis in these cell lines was accompanied by caspase-3 activation and poly(ADP-ribose) polymerase fragmentation. Normal ovarian epithelial cells were not affected by binase, except for a slight decrease of HOSE2 cell viability and the appearance of traces of activated caspase-3, but not the poly(ADP-ribose) polymerase 85-kDA fragment. Binase did not induce alteration of EZH2 protein expression neither, in tumor nor in normal cells. In conclusion, selective binase-induced cell death and apoptosis may serve as a new treatment option against ovarian cancer progression. |
| Keywords |
Binase
Ovarian cancer
Apoptosis
Caspase-3
PARP
EZH2 |
| The name of the journal |
Toxicon
|
| URL |
http://www.sciencedirect.com/science/article/pii/S0041010114003298 |
| Please use this ID to quote from or refer to the card |
https://repository.kpfu.ru/eng/?p_id=98323&p_lang=2 |
| Resource files | |
|
|
Full metadata record  |
| Field DC |
Value |
Language |
| dc.contributor.author |
Ilinskaya Olga Nikolaevna |
ru_RU |
| dc.contributor.author |
Nesmelov Aleksandr Aleksandrovich |
ru_RU |
| dc.date.accessioned |
2014-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2014-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2014 |
ru_RU |
| dc.identifier.citation |
Azat R. Garipov, Alexander A. Nesmelov, Hector A. Cabrera-Fuentes, Olga N. Ilinskaya, Bacillus intermedius ribonuclease (BINASE) induces apoptosis in human ovarian cancer cells, Toxicon, Volume 92, 15 December 2014, Pages 54-59, ISSN 0041-0101, http://dx.doi.org/10.1016/j.toxicon.2014.09.014. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/eng/?p_id=98323&p_lang=2 |
ru_RU |
| dc.description.abstract |
Toxicon |
ru_RU |
| dc.description.abstract |
The cytotoxic effects ofBacillus intermediusRNase (binase) towards ovarian cancer cells
(SKOV3 and OVCAR5) were studied in comparison to normal ovarian epithelial cells (HOSE1
and HOSE2). Binase decreased viability and induced the selective apoptosis of ovarian cancer
cells. The apoptosis rate was 50% in SKOV3 and 48% in OVCAR5 cells after 24 h of binase treatment (50 mg/ml). Binase-induced apoptosis in these cell lines was accompanied by caspase-3 activation and poly(ADP-ribose) polymerase fragmentation. Normal ovarian epithelial cells were not affected by binase, except for a slight decrease of HOSE2 cell viability and the appearance of traces of activated caspase-3, but not the poly(ADP-ribose) polymerase 85-kDA fragment. Binase did not induce alteration of EZH2 protein expression neither, in tumor nor in normal cells. In conclusion, selective binase-induced cell death and apoptosis may serve as a new treatment option against ovarian cancer progression. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
|
ru_RU |
| dc.title |
Bacillus intermedius ribonuclease (BINASE) induces apoptosis
in human ovarian cancer cells |
ru_RU |
| dc.type |
Articles in international journals and collections |
ru_RU |
|
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